Placenta-bound immunoglobulins

Elution and partial characterization of immunoglobulins bound to ovine placenta.

Immunoglobulins were eluted from ovine placentae and characterized by immunoprecipitation, electrophoresis, western blotting and ELISA. IgG was shown to comprise the bulk of placental-bound immunoglobulins while smaller amounts of IgM and only trace amounts of IgA were demonstrated. Results suggest that ovine placental IgG eluted by surgical cannulation of the uterine blood vessels in situ is s...

Small quantities of erythrocyte bound immunoglobulins and autoimmune haemolysis.

Enzyme linked and radioimmune direct antiglobulin tests (DAGTs) were used to assess red cell bound IgG, IgA, and IgM in 585 patients referred to an immunohaematology reference centre. One hundred and fifty eight patients with less than or equal to 200 mol IgG and small amounts of IgA and IgM coating their red cells were studied in detail. The presence of autoimmune haemolysis was determined fro...

Macrophage-cytophilic antibodies and the functions of macrophage-bound immunoglobulins.

Production and Physicochemical Characteristics.................................. 368 Rabbits.................................................................. 368 Guinea pigs............................................................... 369 Mice................................................................... 369 Rats................................................................... 370 Pou...

Gestation age dependent transfer of human immunoglobulins across placenta in timed-pregnant guinea pigs

INTRODUCTION When administered during pregnancy, antibodies and other biologic drugs that contain the Fc part of the IgG molecule can traverse the placenta. Although it is generally accepted that the FcRn receptor mediates this process, gaps remain in our understanding of underlying details in humans and in common laboratory animal species. METHODS We expanded our previous studies in timed-pr...

Histological and immunohistochemical studies on the localization of immunoglobulins in porcine placenta.